The Italy forward comes into the Reds XI at Anfield, with only Caoimhin Kelleher and Darwin Nunez retaining their places from the side deployed against AFC Bournemouth on Saturday.
Joe Gomez captains the team against the Hammers.
Liverpool: Kelleher, Gomez, Endo, Nunez, Chiesa, Jones, Gakpo, Jota, Tsimikas, Quansah, Bradley.
Subs: Jaros, Van Dijk, Diaz, Szoboszlai, Mac Allister, Salah, Robertson, Alexander-Arnold, Morton.
