Yana Daniels, Jenna Clark, Hannah Silcock and Leanne Kiernan are the alterations and have been selected to start at St Helens Stadium for the 6pm GMT kick-off.
Academy player Neve McDonald has also been included on the bench by Matt Beard in her first inclusion in a matchday squad.
Liverpool: Micah, Daniels, Clark, Fisk, Silcock, Hinds, Nagano, Shaw, Holland, Kiernan, Kapocs.
Subs: Laws, Spencer, Matthews, Smith, Enderby, Bonner, Fahey, Duffy, McDonald.
