Cody Gakpo, Curtis Jones, Andy Robertson and Mohamed Salah come into the Reds line-up for the Merseyside derby.
They replace the injured Hugo Ekitike, as well as Jeremie Frimpong, Milos Kerkez and Alexis Mac Allister.
Liverpool: Mamardashvili, Van Dijk, Konate, Wirtz, Szoboszlai, Isak, Salah, Jones, Gakpo, Robertson, Gravenberch.
Subs: Woodman, Pecsi, Kerkez, Mac Allister, Chiesa, Frimpong, Nyoni, Ngumoha.
