Freddie Woodman and Kieran Morrison are handed debuts for the Reds at Anfield, with only Milos Kerkez retaining his place in the side that began at Brentford on Saturday.
Andy Robertson captains the team, while there are also starts for Federico Chiesa, Wataru Endo, Joe Gomez and Alexis Mac Allister.
Liverpool: Woodman, Gomez, Endo, Kerkez, Mac Allister, Chiesa, Robertson, Nyoni, Ramsay, Morrison, Ngumoha.
Subs: Pecsi, Gordon, Kone-Doherty, Pinnington, Figueroa, Nallo, Pilling, Lucky, Laffey.
